runx2

Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the RUNX2 gene. RUNX2 is a key transcription factor associated with osteoblast differentiation. It has also been suggested that Runx2 plays a cell proliferation regulatory role in cell

Aliases: RUNX2, AML3, CBF-alpha-1, CBFA1,

The RUNX2 gene provides instructions for making a protein that is involved in the development and maintenance of the teeth, bones, and cartilage. Cartilage is a tough, flexible tissue that makes up much of the skeleton during early development. Most cartilage is

RUNX2 (RUNX Family Transcription Factor 2) is a Protein Coding gene. Diseases associated with RUNX2 include Cleidocranial Dysplasia and Metaphyseal Dysplasia With Maxillary Hypoplasia With Or Without Brachydactyly.

RUNX2 in Bone Development and Leukemia RUNX2 is known as a master regulator of bone development. The human autosomal-dominant bone disorder, cleidocranial dysplasia (CCD), is due to haploinsufficiency of RUNX2 (Mundlos et al., 1997).

RUNX2 研究进展 顾新丰 , 蒋垚 上海交通大学附属第六人民医院骨科 上海市 , 200233 【 摘要 】 RUNX2 是转录因子 RUNXX 家族成员之一 , 作为成骨细胞的特异转录因子 , 对骨组织的形成和 重建起着重要作用 。 RUNX2 决定着多能干细胞向成骨细胞分化 , 促进

Read: 10540

27/8/2019 · Runx2 (runt-related transcription factor 2) regulates survivin expression in prostate cancer cells Data show that the FGF2-induced ERK MAP kinase strongly increased the Runx2 protein level through an increase in acetylation and a decrease in ubiquitination.

Defects in RUNX2 are the cause of cleidocranial dysplasia (CLCD) [MIM:119600]; also known as cleidocranial dysostosis (CCD). CLCD is an autosomal dominant skeletal disorder with high penetrance and variable expressivity. It is due to defective endochondral and

5/5(14)

RUNX2 has 6,313 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or

Typical features include hypoplasia/aplasia of clavicles, patent fontanelles, wormian bones (additional cranial plates caused by abnormal ossification of the calvaria), supernumerary teeth, short stature, and other skeletal changes. In some cases defects in RUNX2

Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5′-PYGPYGGT-3′, of a number of enhancers and

Annotation score: 5 out of 5

RUNX2 has 6,313 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or

RUNX2 Antibody (F-2) is a mouse monoclonal IgG 1 (kappa light chain) provided at 200 µg/ml raised against amino acids 294-363 of RUNX2 of mouse origin RUNX2 Antibody (F-2) is recommended for detection of RUNX2 of mouse, rat and human origin by WB, IP

4.6/5(25)

RUNX2 (Runt-related transcription factor 2) Fluorescence in situ hybridization with SureFISH RUNX2 probe (Agilent Technologies, US) showing RUNX2 located on 6p21.1 (red signals) –

Mouse monoclonal antibody raised against a partial recombinant RUNX2. RUNX2 (NP_004339, 251 a.a. ~ 350 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. (H00000860-M01) – Products – Abnova

Runx2 is highly expressed in osteoblasts as well as prehypertrophic and hypertrophic chondrocytes [123, 124]. Mice lacking Runx2 lack a mineralized skeleton and thus die within minutes of birth as a result of an inability to breathe [123].

3323 target genes of the RUNX2 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. Symbol Name A2M alpha-2-macroglobulin A2ML1 alpha-2

Looking for online definition of RUNX2 or what RUNX2 stands for? RUNX2 is listed in the World’s largest and most authoritative dictionary database of abbreviations and acronyms RUNX2 – What does RUNX2 stand for? The Free Dictionary https://acronyms

2/5/2017 · Association of gene variants of transcription factors PPARγ, RUNX2, Osterix genes and COL2A1, IGFBP3 genes with the development of osteonecrosis of the femoral head in Chinese population. Song Y(1), Du Z(2), Ren M(1), Yang Q(3), Wang Q(3), Chen G(3

The RUNX2 gene encodes a Runt-related transcription factor, which is part of the RUNX gene family (see RUNX1, 151385 and RUNX3, 600210). The RUNX transcription factors are composed of an alpha subunit, encoded by the RUNX1, RUNX2, and RUNX3 genes

RUNX2 References Further reading External links RUNX3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain

Function ·

Runx2与成骨细胞分化分化调控_生物学_自然科学_专业资料 1039人阅读|53次下载 Runx2与成骨细胞分化分化调控_生物学_自然科学_专业资料。17 2005 1 2 Chinese Bulletin of Life Sciences Vol. 17, No. 1 Feb., 2005 1004-0374(2005)01-0040-05

RUNX2 Antibody (C-12) is a mouse monoclonal IgG 1 (kappa light chain) provided at 200 µg/ml raised against amino acids 294-363 of RUNX2 of mouse origin RUNX2 Antibody (C-12) is recommended for detection of RUNX2 of mouse, rat and human origin by WB, IP

5/5(6)

RUNX2 overexpression and PTEN haploinsufficiency cooperate to promote CXCR7 expression and cellular trafficking, AKT hyperactivation and prostate tumorigenesis Yang Bai 1,2*, Yinhui Yang 1,2*, Yuqian Yan 2, Jian Zhong 2, Alexandra M. Blee 2 2, Tao Ma 2

 · PDF 檔案

RUNX2 (F-2) is also recommended for detection of RUNX2 in additional species, including equine, bovine and porcine. Suitable for use as control antibody for RUNX2 siRNA (h): sc-37145, RUNX2

Human RUNX2 partial ORF ( NP_001019801.1, 311 a.a. – 450 a.a.) recombinant protein with GST-tag at N-terminal. (H00000860-Q02) – Products – Abnova Innovate

Abcam – antibodies and reagents supplier, find any antibody Check out our protocols Visit protocols and troubleshooting or check them out using the Abcam app for iPhone Protocols and troubleshooting

Chromatin immunoprecipitations were performed with cross-linked chromatin from Saos-2 cells and either RUNX2 (D1H7) Rabbit mAb or Normal Rabbit IgG #2729 using SimpleChIP® Enzymatic Chromatin IP Kit (Magnetic Beads) #9003. The enriched DNA was

Runx2 is an essential transcription factor for osteoblast differentiation. However, the functions of Runx2 in postnatal bone development remain to be clarified. Introduction of dominant‐negative (dn)‐Runx2 did not inhibit Col1a1 and osteocalcin expression in mature

 · PDF 檔案

Immunoprecipitation of RUNX2 from Saos-2 cell extracts, using Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (lane 2) or RUNX2 (D1L7F) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot analysis was performed using RUNX2 (D1L7F) Rabbit mAb. 00

Runx2能直接刺激骨髓间充质细胞向 成骨细胞分化过程中骨钙素、I型胶原、骨桥蛋白和胶原酶3 等基因的转录口J。目前为止,Runx2的分子机制还尚不清楚, 现从7个方面综述Rtmx2的功能。 1依赖细胞外基质(extraeellular matrix

 · PDF 檔案

Immunoprecipitation of RUNX2 from Saos-2 cell extracts, using Rabbit (DA1E) mAb IgG XP® Isotype Control #3900 (lane 2) or RUNX2 (D1L7F) Rabbit mAb (lane 3). Lane 1 is 10% input. Western blot analysis was performed using RUNX2 (D1L7F) Rabbit mAb. 00

Runx2 synonyms, Runx2 pronunciation, Runx2 translation, English dictionary definition of Runx2. abbr. 1. charge-coupled device 2. Confraternity of Christian Doctrine abbreviation for charge-coupled device charge-coupled device: a semiconductor chip

qSTAR qPCR primer pairs against Mus musculus gene Runx2 Product Data Gene ID 12393 Forward Sequence CCTGAACTCTGCACCAAGTCCT Reverse Sequence TCATCTGGCTCAGATAGGAGGG Accession No NM_001145920, NM_001146038, NM

Runx2 Suppresses Estrogen Activity —Because complex formation with Runx2 involves the DBD of ERα (Figs. 4 and 5), Runx2 could possibly counter-regulate estrogen activity. Indeed, forced expression of Runx2 dose-dependently decreased the

16/5/2019 · Therefore, we overexpressed or shRNA silenced RUNX2 gene in LoVo and SW620 cells, and found a positive role of RUNX2 in promoting migration of CRC cells (Fig. 7a, b). In the in vivo mouse models, overexpressing of RUNX2 promoted the lung and liverRUNX2

 · PDF 檔案

271 www.ecmjournal.org M ruderer et al. RUNX2 in osteogenesis Fig. 1. (A) Expression of Runx2 isoforms in human. The two Runx2 mRNA types are derived from two different Runx2 promoters, P1 and P2: promoter P2 accounts for the

27/2/2007 · Runx2 Protein Is Stable During Mitosis and Associated with Mitotic Chromosomes. Runx2, a tissue-specific transcription factor that confers cell fate and lineage commitment, is organized in multiple distinct subnuclear foci during interphase (). Here we show that

RUNX2 A gene on chromosome 6p21 that encodes a nuclear protein member of the RUNX family of transcription factors with a Runt DNA-binding domain. RUNX2 is essential for osteoblastic differentiation and skeletal morphogenesis, and acts as a scaffold for

求问成骨相关基因(ALP,COL-I,OCN,OPN,RUNX2)的表达之间会互相影响吗?互相之间有什么关系?每个基因是怎么样影响细胞成骨方向的分化?有没有相关书籍或者文献综述专门介绍这方面的啊? 分子生物

 · PDF 檔案

Expression of OPG, RANKL, and RUNX2 in rabbit periodontium under orthodontic force B. Li1, Y.H. Zhang 2, L.X. Wang3, X. Li4 and X.D. Zhang5 1Department of Stomatology, Oriental Hospital of Beijing University of Chinese Medicine, Beijing, China 2